Benzimidazoles and isosteric compounds as potent and selective factor Xa inhibitors

Bioorg Med Chem Lett. 2002 Mar 25;12(6):919-22. doi: 10.1016/s0960-894x(02)00056-2.

Abstract

Benzimidazoles and their isosteric compounds as factor Xa inhibitors are discussed.

MeSH terms

  • Animals
  • Benzimidazoles / chemical synthesis
  • Benzimidazoles / pharmacology*
  • Enzyme Inhibitors / chemical synthesis
  • Enzyme Inhibitors / pharmacology
  • Factor Xa / metabolism
  • Factor Xa Inhibitors*
  • Heterocyclic Compounds, 4 or More Rings / chemical synthesis
  • Heterocyclic Compounds, 4 or More Rings / pharmacology
  • Humans
  • Kinetics
  • Structure-Activity Relationship

Substances

  • Benzimidazoles
  • Enzyme Inhibitors
  • Factor Xa Inhibitors
  • Heterocyclic Compounds, 4 or More Rings
  • Factor Xa