Abstract
Several amines, amino acid derivatives and low molecular weight peptides containing an amide-bound oxal hydroxamic acid moiety have been synthesized and tested for their inhibitory effects towards native human gelatinase B (MMP-9) and the catalytic domains of the membrane type MT1-MMP (MMP-14) and of neutrophil collagenase (MMP-8). A number of these compounds exhibited considerable inhibitory activity against the tested metalloproteinases.
MeSH terms
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Amines / chemical synthesis
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Amines / pharmacology
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Amino Acids / chemical synthesis
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Amino Acids / pharmacology
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Catalytic Domain
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Humans
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Hydroxamic Acids / chemical synthesis
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Hydroxamic Acids / chemistry
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Hydroxamic Acids / pharmacology*
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Matrix Metalloproteinase 8 / chemistry
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Matrix Metalloproteinase 9 / chemistry
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Matrix Metalloproteinase Inhibitors*
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Matrix Metalloproteinases / chemistry
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Oligopeptides / chemical synthesis
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Oligopeptides / pharmacology
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Structure-Activity Relationship
Substances
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Amines
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Amino Acids
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Hydroxamic Acids
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Matrix Metalloproteinase Inhibitors
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Oligopeptides
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Matrix Metalloproteinases
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Matrix Metalloproteinase 8
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Matrix Metalloproteinase 9