Abstract
Nineteen of 27 ceftazidime-resistant Enterobacter cloacae isolates from a neonatal intensive care unit in Thessaloniki, Greece, had genes coding for the novel extended-spectrum beta-lactamase IBC-1; 18 of those 19 harbored similar conjugative plasmids and belonged to two distinct genetic lineages. A synergy test with ceftazidime and imipenem enabled us to identify five unrelated bla(IBC-1)-carrying E. cloacae isolates from other wards of the hospital. It seems that this integron-associated gene is capable of dispersing both by clonal spread and by gene dissemination.
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Ceftazidime / pharmacology
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Cephalosporin Resistance
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Disease Outbreaks*
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Enterobacter cloacae / drug effects
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Enterobacter cloacae / enzymology*
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Enterobacter cloacae / genetics
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Enterobacteriaceae Infections / epidemiology*
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Enterobacteriaceae Infections / microbiology
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Greece / epidemiology
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Hospitals, University
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Humans
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Infant, Newborn
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Infant, Premature*
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Integrases / genetics
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Intensive Care, Neonatal*
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Microbial Sensitivity Tests
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beta-Lactamases / genetics*
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beta-Lactamases / metabolism
Substances
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Anti-Bacterial Agents
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Ceftazidime
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Integrases
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integron integrase IntI1
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integron-associated beta-lactamase 1
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beta-Lactamases