Abstract
The impact of different types of enzymatic resistance on the in vivo antibacterial activity of aminoglycosides (amikacin, gentamicin, and netilmicin) was studied in the rabbit endocarditis model with four strains of Staphylococcus aureus. Animals were treated in a manner simulating the administration of a single daily human dose. Amikacin had no effect on the three kanamycin-resistant strains despite apparent susceptibility in the disk diffusion test. Gentamicin appears to be the preferable aminoglycoside for treatment of staphylococcal infections.
MeSH terms
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Aminoglycosides
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Animals
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Anti-Bacterial Agents / pharmacokinetics
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Anti-Bacterial Agents / pharmacology*
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Anti-Bacterial Agents / therapeutic use*
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Colony Count, Microbial
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Disease Models, Animal
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Drug Resistance, Bacterial*
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Endocarditis, Bacterial / drug therapy
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Endocarditis, Bacterial / microbiology*
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Female
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Humans
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Microbial Sensitivity Tests
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Rabbits
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Staphylococcal Infections / drug therapy
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Staphylococcal Infections / microbiology*
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Staphylococcus aureus / drug effects*
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Staphylococcus aureus / enzymology
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Staphylococcus aureus / growth & development
Substances
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Aminoglycosides
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Anti-Bacterial Agents