Abstract
Steaming ginseng at high temperature increased its cytotoxicity to SK-Hep-1 hepatoma cancer cells. HPLC separation and fractionation followed by MTT assay revealed that ginsenosides Rg3, Rg5, Rk1, Rs5, and Rs4 are the active principles. Their 50% growth inhibition concentration (GI50) values were 41, 11, 13, 37, and 13 microM, respectively. Cisplatin had a GI50 of 84 microM in the same assay conditions.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Carcinoma, Hepatocellular / pathology
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Cell Survival / drug effects
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Chromatography, High Pressure Liquid
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Cisplatin / pharmacology
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Dammaranes
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Ginsenosides / chemistry
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Ginsenosides / isolation & purification
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Ginsenosides / pharmacology
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Glycosides / chemistry
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Glycosides / isolation & purification*
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Glycosides / pharmacology
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Liver Neoplasms / pathology
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Panax / chemistry*
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Plant Extracts / chemistry
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Plant Roots / chemistry
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Temperature
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents, Phytogenic
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Ginsenosides
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Glycosides
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Plant Extracts
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Triterpenes
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Cisplatin