Description of fourteen new DRB alleles found in a stem cell donor registry

T F Tang; Y-S Lin; F-M Robbins; L Li; D Sintasath; G Coquillard; A Huang; U Heine; J Ng; R J Hartzman; C K Hurley

doi:10.1034/j.1399-0039.2002.590115.x

Description of fourteen new DRB alleles found in a stem cell donor registry

Tissue Antigens. 2002 Jan;59(1):63-5. doi: 10.1034/j.1399-0039.2002.590115.x.

Authors

T F Tang¹, Y-S Lin, F-M Robbins, L Li, D Sintasath, G Coquillard, A Huang, U Heine, J Ng, R J Hartzman, C K Hurley

Affiliation

¹ Department of Pediatrics, Georgetown University, Washington, DC, USA.

PMID: 11972885
DOI: 10.1034/j.1399-0039.2002.590115.x

Abstract

Fourteen DRB alleles, DRB1*0705, DRB1*11014, DRB1*1134, DRB1*1136, DRB1*1141, DRB1*1335, DRB1*1337, DRB1*1338, DRB1*1342, DRB1*1343, DRB1*1349, DRB1*1510, DRB3*0105, and DRB5*0103, are described. Among them, eleven are variants which differ by only one nucleotide from previously described alleles, including one silent variant (DRB1*11014). Alleles, DRB1*0705, DRB1*1335 and DRB3*0105, display unique sequence motifs that have never been observed in DRB alleles.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Alleles*
HLA-DR Antigens / genetics*
HLA-DRB1 Chains
HLA-DRB3 Chains
HLA-DRB5 Chains
Humans
Registries
Sequence Analysis, DNA
Stem Cells*
Tissue Donors

Substances

HLA-DR Antigens
HLA-DRB1 Chains
HLA-DRB3 Chains
HLA-DRB5 Chains