Scaffolds, adaptors and linkers of TCR signaling: theory and practice

Curr Opin Immunol. 2002 Jun;14(3):312-6. doi: 10.1016/s0952-7915(02)00347-3.

Abstract

Four non-enzymatic proteins form the structural core of the TCR signaling machinery, linking antigen-receptor activation to signaling. These four proteins, each with well defined protein-protein interaction domains, include three 'scaffolds' (LAT, SLP-76 and SLAP-130/Fyb/ADAP and a 'pure adaptor' (GADS). The biological functions of many distinct protein-protein interaction domains have been dissected through a methodological series of knockout and reconstitution experiments. In reviewing these recent advances, we attempt to address two questions often asked by immunologists not familiar with the field: what do scaffolds/adaptors/linkers do; and what do these terms mean?

Publication types

  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing*
  • Animals
  • Carrier Proteins / physiology
  • GRB2 Adaptor Protein
  • Humans
  • Phosphoproteins / physiology
  • Proteins / physiology
  • Receptors, Antigen, T-Cell / physiology*
  • Signal Transduction / physiology*

Substances

  • Adaptor Proteins, Signal Transducing
  • Carrier Proteins
  • FYB1 protein, human
  • GRAP2 protein, human
  • GRB2 Adaptor Protein
  • GRB2 protein, human
  • Phosphoproteins
  • Proteins
  • Receptors, Antigen, T-Cell
  • SLP-76 signal Transducing adaptor proteins