Abstract
A new malyngamide, S (1), was isolated from a New Zealand collection of the sea hare Bursatella leachii and structurally characterized by spectroscopic methods and chemical degradation. Malyngamide S exhibited cytotoxicity and antiinflammatory properties.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / isolation & purification*
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Anti-Inflammatory Agents / pharmacology
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Bacillus subtilis / drug effects
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Chromatography, High Pressure Liquid
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Cyclohexanones / chemistry
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Cyclohexanones / isolation & purification*
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Cyclohexanones / pharmacology
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Drug Screening Assays, Antitumor
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Escherichia coli / drug effects
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Fatty Acids, Monounsaturated / chemistry
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Fatty Acids, Monounsaturated / isolation & purification*
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Fatty Acids, Monounsaturated / pharmacology
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HL-60 Cells
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Humans
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Leukemia P388
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Mice
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Molecular Structure
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Mollusca / chemistry*
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Mycobacterium tuberculosis / drug effects
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New Zealand
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Nuclear Magnetic Resonance, Biomolecular
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Tumor Cells, Cultured / drug effects
Substances
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7S-methoxydodec-4E-enoic acid
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Anti-Inflammatory Agents
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Antineoplastic Agents
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Cyclohexanones
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Fatty Acids, Monounsaturated
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malyngamide S