Intragenic breakpoint within RAD51L1 in a t(6;14)(p21.3;q24) of a pulmonary chondroid hamartoma

Cytogenet Cell Genet. 2001;95(1-2):17-9. doi: 10.1159/000057011.

Abstract

Rearrangements involving chromosome region 14q23-->q24 represent a main cytogenetic subgroup in a variety of benign solid tumors. Recently, in uterine leiomyomas containing the classical t(12;14)(q15;q23-->q24), the primary chromosome 14 target gene was identified as the protein kinase-encoding gene RAD51L1. In this report we show that RAD51L1 is also involved in the frequently occurring t(6;14) (p21;q23-->q24) in pulmonary chondroid hamartomas.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosome Breakage / genetics*
  • Chromosomes, Human, Pair 14 / genetics*
  • Chromosomes, Human, Pair 6 / genetics*
  • DNA-Binding Proteins / genetics*
  • Exons / genetics
  • Hamartoma / genetics*
  • Humans
  • In Situ Hybridization, Fluorescence
  • Lung Diseases / genetics*
  • Physical Chromosome Mapping
  • Rad51 Recombinase
  • Translocation, Genetic / genetics*

Substances

  • DNA-Binding Proteins
  • RAD51 protein, human
  • Rad51 Recombinase