The mechanism and regulation of chromosomal V(D)J recombination

Cell. 2002 Apr:109 Suppl:S45-55. doi: 10.1016/s0092-8674(02)00675-x.

Abstract

V(D)J recombination is of fundamental importance to the generation of diverse antigen receptor repertoires. We review our current understanding of the V(D)J recombination reaction and how it is regulated during lymphocyte development. We also discuss how defects in the mechanism or regulation of V(D)J recombination can lead to human disease.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Chromosomes / genetics*
  • DNA Nucleotidyltransferases / metabolism
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism
  • Gene Expression Regulation
  • Gene Rearrangement / genetics*
  • Genes, Immunoglobulin / genetics*
  • Homeodomain Proteins / genetics
  • Homeodomain Proteins / metabolism
  • Humans
  • Immune System Diseases / genetics
  • Lymphocytes / cytology
  • Lymphocytes / immunology
  • Nuclear Proteins
  • Recombination, Genetic / genetics*
  • VDJ Recombinases

Substances

  • DNA-Binding Proteins
  • Homeodomain Proteins
  • Nuclear Proteins
  • RAG2 protein, human
  • V(D)J recombination activating protein 2
  • RAG-1 protein
  • DNA Nucleotidyltransferases
  • VDJ Recombinases