Changes in the expression of metabotropic glutamate receptor 5 (mGluR5) in the rat hippocampus in an animal model of depression

J M Wierońska; P Brański; B Szewczyk; A Pałucha; M Papp; P Gruca; E Moryl; A Pilc

Changes in the expression of metabotropic glutamate receptor 5 (mGluR5) in the rat hippocampus in an animal model of depression

Pol J Pharmacol. 2001 Nov-Dec;53(6):659-62.

Authors

J M Wierońska¹, P Brański, B Szewczyk, A Pałucha, M Papp, P Gruca, E Moryl, A Pilc

Affiliation

¹ Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Kraków.

PMID: 11985342

Abstract

The aim of our study was to investigate the level of metabotropic glutamate receptors (mGluRs) in the brains of rats after chronic mild stress. Using Western blotting procedure we showed that the level of mGluR5 receptor protein was increased in CA1 and decreased in CA3 region of the hippocampus. Our results indicate that mGluR5 can possibly be engaged in the mechanism of depression.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Blotting, Western
Chronic Disease
Dentate Gyrus / metabolism
Depression / etiology
Depression / metabolism*
Electrophoresis, Polyacrylamide Gel
Hippocampus / metabolism*
Male
Rats
Rats, Wistar
Receptor, Metabotropic Glutamate 5
Receptors, Metabotropic Glutamate / metabolism*
Stress, Psychological / complications

Substances

Grm5 protein, rat
Receptor, Metabotropic Glutamate 5
Receptors, Metabotropic Glutamate