Successful multimodality therapy of recurrent multifocal juvenile granulosa cell tumor of the ovary

J Pediatr Hematol Oncol. 2002 Mar-Apr;24(3):229-33. doi: 10.1097/00043426-200203000-00015.

Abstract

Juvenile granulosa cell tumor (JGCT) of the ovary, a rare pediatric cancer, carries a very poor prognosis in advanced and recurrent cases. A 10-year-old girl with stage IA JGCT, initially treated with resection only, presented with extensive unresectable multifocal pelvic recurrence. She underwent surgery, chemotherapy (cisplatin/paclitaxel alternating with cisplatin/cyclophosphamide/etoposide/bleomycin), myeloablative chemotherapy (carboplatin/etoposide/melphalan) with autologous bone marrow transplant, and pelvic radiation. She tolerated therapy well and is in complete remission 69 months after her recurrence.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Bone Marrow Transplantation
  • Child
  • Combined Modality Therapy
  • Disease-Free Survival
  • Female
  • General Surgery
  • Granulosa Cell Tumor / pathology
  • Granulosa Cell Tumor / therapy*
  • Humans
  • Neoplasm Recurrence, Local / pathology
  • Neoplasm Recurrence, Local / therapy*
  • Ovarian Neoplasms / pathology
  • Ovarian Neoplasms / therapy*
  • Treatment Outcome