Phosphotyrosine-binding domains in signal transduction

Michael B Yaffe

doi:10.1038/nrm759

Phosphotyrosine-binding domains in signal transduction

Nat Rev Mol Cell Biol. 2002 Mar;3(3):177-86. doi: 10.1038/nrm759.

Author

Michael B Yaffe¹

Affiliation

¹ Center for Cancer Research, E18-580, Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139-4307, USA. [email protected]

PMID: 11994738
DOI: 10.1038/nrm759

Abstract

Protein phosphorylation provides molecular control of complex physiological events within cells. In many cases, phosphorylation on specific amino acids directly controls the assembly of multi-protein complexes by recruiting phospho-specific binding modules. Here, the function, structure, and cell biology of phosphotyrosine-binding domains is discussed.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Animals
Binding Sites
Humans
Ligands
Models, Biological
Models, Molecular
Phosphotyrosine / metabolism*
Protein Structure, Tertiary
Receptors, Growth Factor / chemistry
Receptors, Growth Factor / physiology
Signal Transduction / physiology*
src Homology Domains

Substances

Ligands
Receptors, Growth Factor
Phosphotyrosine