In this study, the authors have as a goal to discuss the care-investigation interface in the caring practice of Nursing in the hospital ambit, starting from their professional experiences. The bases of the discussion is the career/cared being. We surpass care as the object of research and the importance of investigation for the improvement of care quality. Interdisciplinarity is pointed out as one of the possible resources for the construction of integral care and of a therapeutical action that exceeds the biological, in a perspective of co-participation, as well as the need of promoting and stimulating the accomplishment of investigations in the units of hospital care. The meaning of the investigation about care goes beyond its internality, requiring technical competence, ethical compromise and coherence among the different areas of knowledge which involves it. We enlighten the need of overcoming the dichotomies of caring/investigating, researching while caring, and caring while researching. We stress out the importance of creating research groups in Universities; the stimulus to the accomplishment of graduation courses with leave-out time from work; the availability of financial resources; and the incentive to subscribe periodicals and to acquire books.