Synthesis and cholera toxin binding properties of a lactose-2-aminothiazoline conjugate

Ioannis Vrasidas; Johan Kemmink; Rob M J Liskamp; Roland J Pieters

doi:10.1021/ol025909w

Synthesis and cholera toxin binding properties of a lactose-2-aminothiazoline conjugate

Org Lett. 2002 May 16;4(10):1807-8. doi: 10.1021/ol025909w.

Authors

Ioannis Vrasidas¹, Johan Kemmink, Rob M J Liskamp, Roland J Pieters

Affiliation

¹ Department of Medicinal Chemistry, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, P.O. Box 80082, 3508 TB, The Netherlands.

PMID: 12000304
DOI: 10.1021/ol025909w

Abstract

[structure: see text] During the search for improved monovalent ligands for cholera toxin (CT), a new lactose-2-aminothiazoline conjugate was discovered. In a fluorescence binding assay the compound was found to be one of the strongest relatively simple CT ligands to date with a K(d) of 23 microM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carbohydrate Sequence
Cholera Toxin / chemistry*
Disaccharides / chemistry*
Ligands
Magnetic Resonance Spectroscopy
Molecular Sequence Data
Thiazoles / chemistry*

Substances

Disaccharides
Ligands
Thiazoles
lactose-2-aminothiazoline
Cholera Toxin