Abstract
Tax is a transcription activator encoded by human T-cell leukemia virus (HTLV)-1. Ribosomal protein L6 was also defined as Taxreb107 (Tax responsible element binding protein 107) for its activity of binding to the long terminal repeats of HTLV-1. To investigate the relationship between Tax and Taxreb107/RpL6, yeast two hybrid and GST pull-down assays were used. Results suggest that Tax can interact with Taxreb107/RpL6 directly and Taxreb107/RpL6 may regulate the function of Tax in HTLV-1 proliferation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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DNA, Complementary / genetics
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Gene Products, tax / genetics
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Gene Products, tax / metabolism*
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Glutathione Transferase / genetics
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Glutathione Transferase / metabolism
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Human T-lymphotropic virus 1 / metabolism*
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Humans
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Mice
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Protein Binding
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Recombinant Fusion Proteins / genetics
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Recombinant Fusion Proteins / metabolism
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Ribosomal Proteins / genetics
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Ribosomal Proteins / metabolism*
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Saccharomyces cerevisiae / genetics
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Two-Hybrid System Techniques
Substances
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DNA, Complementary
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Gene Products, tax
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Recombinant Fusion Proteins
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Ribosomal Proteins
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ribosomal protein L6
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Glutathione Transferase