Abstract
In mice injected intravenously with Candida albicans, administration of anti-interleukin-18 (IL-18) antibodies increased the yeast load in the kidneys. There was no effect on the organ load with Candida when gamma interferon (IFN-gamma)-deficient mice were treated with anti-IL-18 antibodies, suggesting that the protective effect of IL-18 is mediated through endogenous IFN-gamma.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Candida albicans / immunology
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Candidiasis / blood
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Candidiasis / immunology*
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Disease Models, Animal
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Female
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Interferon-gamma / genetics
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Interferon-gamma / immunology*
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Interleukin-1 / blood
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Interleukin-18 / blood
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Interleukin-18 / immunology*
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Interleukin-6 / blood
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Kidney / immunology
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Kidney / microbiology
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Male
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Mice
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Mice, Inbred BALB C
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Mice, Inbred C57BL
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Mice, Inbred CBA
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Mice, Knockout
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Tumor Necrosis Factor-alpha / analysis
Substances
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Interleukin-1
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Interleukin-18
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Interleukin-6
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Tumor Necrosis Factor-alpha
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Interferon-gamma