Objective: To establish a simple, rapid genetic diagnostic system for haemophilia B.
Methods: The polymorphisms of eight STR loci in 87 normal persons and 8 haemophilia B families were assayed by PCR and genescan, and the linkage relations were analysed.
Results: Six of the eight STR loci can provide genetic information for haemophilia B, and the heterozygosity is 0.50 approximately 0.83, PIC 0.39 approximately 0.80, and DP 0.66 approximately 0.94.
Conclusion: Combination of multiple STR loci analysis could be effective method for genetic diagnosis of haemophilia B.