The purpose of this study was to examine the efficacy of magnetic resonance imaging (MRI) and ultrasound (US) in determining complete disruptions of the central portion of the forearm interosseous membrane. The midportion of the forearm interosseous ligament was longitudinally incised in 19 fresh-frozen cadaver arms. The specimens were imaged with MRI and US. The MRIs were examined by a hand surgeon, a musculoskeletal radiologist, and a general radiologist, all blinded to the state of the interosseous membrane. The musculoskeletal radiologist and general radiologists read the real-time US images in a consensus fashion. Magnetic resonance imaging showed a 96% accuracy rate, a 100% positive predictive value, a 93% negative predictive value, 93% sensitivity, and 100% specificity. Kappa analysis showed substantial interobserver agreement for MRI. Ultrasound showed a 94% accuracy rate, a 94% positive predictive value, a 100% negative predictive value, 100% sensitivity, and 89% specificity. There was no statistical significance between the accuracy of MRI and US. We conclude that MRI and US imaging should both be considered when forearm interosseous membrane integrity is in question.