Abstract
N-Chlorotaurine, an endogenous long-lived oxidant, demonstrated fungicidal activity against Candida spp. and a postantifungal effect. Secreted aspartyl proteinases, important fungal virulence factors, proved to be a first target of impact. These results provide support for the topical application of N-chlorotaurine as an antimicrobial agent in yeast infections.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aspartic Acid Endopeptidases / antagonists & inhibitors*
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Candida / drug effects*
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Candida / enzymology*
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Candida / growth & development
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Microbial Sensitivity Tests
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Protease Inhibitors / pharmacology*
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Taurine / analogs & derivatives
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Taurine / pharmacology*
Substances
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Protease Inhibitors
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Taurine
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N-chlorotaurine
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Aspartic Acid Endopeptidases