Abstract
Histopathological changes of biopsied pancreata were examined in three diabetic patients with autoimmune chronic pancreatitis (ACP). We found intra- and periinsular mononuclear cell (MNC)-mainly CD8+ T cell-infiltration as well as MNC infiltration around the ductal cells. Islet beta cell volume decreased significantly. Some ductal cells expressed insulin and insulin promoter factor-1 concomitantly in the affected pancreas. These findings provide new insight toward understanding the pathological mechanisms of corticosteroid treatment-responsive diabetes associated with ACP.
MeSH terms
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Adrenal Cortex Hormones / pharmacology*
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Adrenal Cortex Hormones / therapeutic use
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Aged
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Autoimmune Diseases / complications*
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Autoimmune Diseases / drug therapy
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Autoimmune Diseases / immunology
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Autoimmune Diseases / pathology
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Biopsy
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CD8-Positive T-Lymphocytes / immunology
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Diabetes Complications*
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Diabetes Mellitus / drug therapy*
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Diabetes Mellitus / immunology
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HLA Antigens / immunology
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Humans
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Immunohistochemistry
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Insulin / metabolism
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Islets of Langerhans / drug effects
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Islets of Langerhans / immunology
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Islets of Langerhans / pathology*
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Keratins / metabolism
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Male
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Middle Aged
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Pancreatitis / complications*
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Pancreatitis / drug therapy
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Pancreatitis / immunology
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Pancreatitis / pathology*
Substances
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Adrenal Cortex Hormones
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HLA Antigens
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Insulin
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Keratins