Abstract
We found that PPM1D, encoding a serine/threonine protein phosphatase, lies within an epicenter of the region at 17q23 that is amplified in breast cancer. We show that overexpression of this gene confers two oncogenic phenotypes on cells in culture: attenuation of apoptosis induced by serum starvation and transformation of primary cells in cooperation with RAS.
MeSH terms
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Apoptosis / genetics
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Breast Neoplasms / etiology
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Breast Neoplasms / genetics*
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Cell Transformation, Neoplastic / genetics
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Chromosomes, Human, Pair 17 / genetics*
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Female
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Gene Amplification*
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Humans
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Neoplasm Proteins*
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Oncogenes / genetics
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Phosphoprotein Phosphatases / genetics*
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Protein Phosphatase 2C
Substances
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Neoplasm Proteins
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PPM1D protein, human
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Phosphoprotein Phosphatases
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Protein Phosphatase 2C