Abstract
A major challenge in the post-genomic era is to identify the physiological functions of genes and elucidate the molecular basis for human disease. Genetic polymorphisms offer a convenient avenue for these efforts by providing evidence for the involvement of a given gene in human pathophysiology. Here we review the current evidence linking the low-molecular-weight protein tyrosine phosphatase (LMPTP) to several common diseases, including allergy, asthma, obesity, myocardial hypertrophy, and Alzheimer's disease. Based on the known effects of the genetic polymorphisms on the alternative mRNA splicing and enzyme levels of LMPTP, we discuss the possible molecular mechanisms of LMPTP involvement in these diseases.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Alternative Splicing
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Alzheimer Disease / enzymology
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Alzheimer Disease / genetics
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Arthritis, Rheumatoid / enzymology
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Arthritis, Rheumatoid / genetics
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Asthma / enzymology
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Asthma / genetics
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Brain / enzymology
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Cardiomegaly / enzymology
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Cardiomegaly / genetics
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Diabetes Mellitus / enzymology
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Diabetes Mellitus / genetics
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Embryonic and Fetal Development / physiology
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Favism / enzymology
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Favism / genetics
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Female
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Humans
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Hypersensitivity / enzymology
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Hypersensitivity / genetics
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Inflammatory Bowel Diseases / enzymology
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Inflammatory Bowel Diseases / genetics
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Isoenzymes / genetics*
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Isoenzymes / metabolism*
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Malaria / enzymology
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Malaria / genetics
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Obesity / enzymology
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Obesity / genetics
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Polymorphism, Genetic
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Pregnancy
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Protein Tyrosine Phosphatases / genetics*
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Protein Tyrosine Phosphatases / metabolism*
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Proto-Oncogene Proteins*
Substances
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Isoenzymes
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Proto-Oncogene Proteins
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ACP1 protein, human
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Protein Tyrosine Phosphatases