Solid-phase synthesis of lipidated peptides

J Am Chem Soc. 2002 May 29;124(21):5954-5. doi: 10.1021/ja025768t.

Abstract

Characteristic partial structures of lipidated proteins embodying different lipid groups as well as additional fluorescent tags or a maleimide for coupling to proteins can be synthesized readily by means of a new solid-phase technique employing the oxidative cleavage of the hydrazide linker as well as on-resin farnesylation and palmitoylation after appropriate deprotection of cysteine thiol groups as the key steps.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Lipids / chemical synthesis
  • Lipids / chemistry*
  • Lipoproteins / chemical synthesis*
  • Peptides / chemical synthesis
  • Peptides / chemistry*

Substances

  • Lipids
  • Lipoproteins
  • Peptides