Abstract
AMP-activated protein kinase (AMPK) is a regulator of cellular metabolism in response to changes in the energy status of the cells. AMPK was known to shut down energy-consuming pathways in response to a fall in the ATP/AMP ratio by phosphorylating key enzymes of intermediate metabolism. Here we will discuss the recent evidence implicating AMPK in the regulation of gene expression in mammals, mainly in the liver and in the pancreatic beta-cells.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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AMP-Activated Protein Kinases
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Animals
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Enzyme Activation
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Gene Expression Regulation*
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Humans
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Islets of Langerhans / metabolism
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Liver / metabolism
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Multienzyme Complexes / genetics
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Multienzyme Complexes / metabolism*
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Muscle, Skeletal / metabolism
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Protein Serine-Threonine Kinases / genetics
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Protein Serine-Threonine Kinases / metabolism*
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Saccharomyces cerevisiae / genetics
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Saccharomyces cerevisiae / metabolism
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Signal Transduction
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Transcription, Genetic
Substances
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Multienzyme Complexes
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SNF1-related protein kinases
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Protein Serine-Threonine Kinases
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AMP-Activated Protein Kinases