Synthetic route to the GE3 cyclodepsipeptide

Org Lett. 2002 May 30;4(11):1903-6. doi: 10.1021/ol025895u.

Abstract

[reaction: see text] A reasonably efficient [2 + 2 + 2] fragment condensation strategy has been developed for assembling the cyclodepsipeptide sector of GE3 that involves 5-7. A Carpino HATU-mediated macrolactamization was used to close the 19-membered cyclodepsipeptide ring.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis
  • Antibiotics, Antineoplastic / chemical synthesis*
  • Depsipeptides*
  • Indicators and Reagents
  • Lactams / chemistry
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Peptides*
  • Peptides, Cyclic / chemical synthesis*

Substances

  • Anti-Bacterial Agents
  • Antibiotics, Antineoplastic
  • Depsipeptides
  • GE3 compound
  • Indicators and Reagents
  • Lactams
  • Peptides
  • Peptides, Cyclic
  • A 83586C