Five new iboga alkaloids from Tabernaemontana corymbosa

J Nat Prod. 2002 May;65(5):669-72. doi: 10.1021/np0105432.

Abstract

Five new indole alkaloids of the ibogan type (1-5), in addition to 12 other known iboga alkaloids, were obtained from the leaf and stem-bark extract of the Malayan species Tabernaemontana corymbosa, viz., 19(S)-hydroxyibogamine (1), 19-epi-isovoacristine (2), isovoacryptine (3), 3R/S-ethoxyheyneanine (4), and 3R/S-ethoxy-19-epi-heyneanine (5). The structures were determined using NMR and MS analysis and comparison with known related compounds.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Indole Alkaloids / chemistry
  • Indole Alkaloids / isolation & purification*
  • Malaysia
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Bark / chemistry
  • Plant Leaves / chemistry
  • Plant Stems / chemistry
  • Plants, Medicinal / chemistry*
  • Spectroscopy, Fourier Transform Infrared
  • Stereoisomerism
  • Tabernaemontana / chemistry*

Substances

  • Indole Alkaloids