Abstract
Four new eremophilenolides, 1-4, have been isolated from the whole plant of Ligulariopsis shichuana. Their structures were elucidated by spectroscopic methods, including 2D NMR experiments. Structures of compounds 1 and 2 were unequivocally established by X-ray diffraction experiments. All of these sesquiterpenes have eremophilane skeletons with 7(11)-en-8(12) lactone units. Compounds 1 and 2 showed moderate antibacterial activities against E. coli and B. subtilis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Asteraceae / chemistry*
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Bacillus subtilis / drug effects
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Crystallography, X-Ray
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Escherichia coli / drug effects
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Lactones / chemistry
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Lactones / isolation & purification*
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Lactones / pharmacology
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Molecular Conformation
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plants, Medicinal / chemistry*
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology
Substances
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Anti-Bacterial Agents
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Drugs, Chinese Herbal
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Lactones
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Sesquiterpenes