Propofol reduces spinal motor neuron excitability in humans

Anesth Analg. 2002 Jun;94(6):1586-8, table of contents. doi: 10.1097/00000539-200206000-00040.

Abstract

We investigated in humans whether changes in spinal motor neuron excitability correlate with the predicted propofol concentration (Cpt) achieved by a target-controlled infusion system. Propofol suppressed F-wave persistence in a Cpt-dependent manner, indicating that propofol depresses spinal motor neuron excitability at clinically relevant concentrations.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Anesthesia, Intravenous*
  • Anesthetics, Intravenous* / adverse effects
  • Dose-Response Relationship, Drug
  • Electrophysiology
  • Female
  • Humans
  • Male
  • Median Nerve / cytology
  • Median Nerve / drug effects
  • Membrane Potentials / drug effects
  • Middle Aged
  • Motor Neurons / drug effects*
  • Neurosurgical Procedures*
  • Propofol* / administration & dosage
  • Spinal Cord / cytology
  • Spinal Cord / drug effects*

Substances

  • Anesthetics, Intravenous
  • Propofol