Abstract
The synthesis and fasciolicidal activity of 5-chloro-2-methylthio-6-(1-naphthyloxy)-1H-benzimidazole (6) is described. Compound 6 showed 100% activity in vitro at 146.70 and 29.34 microM concentrations. It also completely removed 3-d and 10-week-old Fasciola hepatica in sheep at a dose of 15 mg/kg.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anthelmintics / chemical synthesis*
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Benzimidazoles / pharmacology
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Crystallization
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Fasciola hepatica / drug effects*
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Fascioliasis / drug therapy
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Fascioliasis / parasitology
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Imidazoles / chemical synthesis*
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Imidazoles / pharmacology*
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Indicators and Reagents
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Naphthalenes / chemical synthesis*
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Naphthalenes / pharmacology*
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Sheep
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Structure-Activity Relationship
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Triclabendazole
Substances
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5-chloro-2-methylthio-6-(1-naphthyloxy)-1H-benzimidazole
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Anthelmintics
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Benzimidazoles
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Imidazoles
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Indicators and Reagents
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Naphthalenes
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Triclabendazole