Pyridazines. Part 28: 5-alkylidene-6-phenyl-3(2H)-pyridazinones, a new family of platelet aggregation inhibitors

Eddy Sotelo; Nuria Fraiz; Matilde Yáñez; Reyes Laguna; Ernesto Cano; José Brea; Enrique Raviña

doi:10.1016/s0960-894x(02)00246-9

Pyridazines. Part 28: 5-alkylidene-6-phenyl-3(2H)-pyridazinones, a new family of platelet aggregation inhibitors

Bioorg Med Chem Lett. 2002 Jun 17;12(12):1575-7. doi: 10.1016/s0960-894x(02)00246-9.

Authors

Eddy Sotelo¹, Nuria Fraiz, Matilde Yáñez, Reyes Laguna, Ernesto Cano, José Brea, Enrique Raviña

Affiliation

¹ Departamento de Química Orgánica, Laboratorio de Química Farmacéutica, Universidad de Santiago de Compostela, 15782-Santiago de Compostela, Spain.

PMID: 12039565
DOI: 10.1016/s0960-894x(02)00246-9

Abstract

The synthesis and anti-platelet activity of several 5-alkylidene-6-phenyl-3(2H)-pyridazinones are described. The most active compounds are those that contain oxygenated functions (COOR, COMe) on the alkylidene fragment (6a, 6b and 6c).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Platelet Aggregation Inhibitors / chemical synthesis*
Platelet Aggregation Inhibitors / chemistry
Platelet Aggregation Inhibitors / pharmacology*
Pyridazines / chemical synthesis*
Pyridazines / chemistry
Pyridazines / pharmacology*
Structure-Activity Relationship

Substances

Platelet Aggregation Inhibitors
Pyridazines