Synthesis and profile of SCH351591, a novel PDE4 inhibitor

Bioorg Med Chem Lett. 2002 Jun 17;12(12):1621-3. doi: 10.1016/s0960-894x(02)00225-1.

Abstract

The syntheses and pharmacological profiles of some 2-trifluoromethyl-8-methoxyquinoline-5-carboxamides are described. SCH351591 is a potent selective inhibitor of phosphodiesterase type 4 (PDE4).

MeSH terms

  • 3',5'-Cyclic-AMP Phosphodiesterases / antagonists & inhibitors*
  • Animals
  • Area Under Curve
  • Cyclic N-Oxides / chemical synthesis*
  • Cyclic N-Oxides / pharmacokinetics
  • Cyclic N-Oxides / pharmacology*
  • Cyclic Nucleotide Phosphodiesterases, Type 4
  • Guinea Pigs
  • Phosphodiesterase Inhibitors / chemical synthesis*
  • Phosphodiesterase Inhibitors / pharmacokinetics
  • Phosphodiesterase Inhibitors / pharmacology*
  • Quinolines / chemical synthesis*
  • Quinolines / pharmacokinetics
  • Quinolines / pharmacology*

Substances

  • Cyclic N-Oxides
  • Phosphodiesterase Inhibitors
  • Quinolines
  • SCH 351591
  • 3',5'-Cyclic-AMP Phosphodiesterases
  • Cyclic Nucleotide Phosphodiesterases, Type 4