Abstract
PAX-6 gene promoter polymorphism, alcohol dependence history and CT were determined in the group of 68 alcoholics. We found negative correlation between numbers of PAX-6 gene promoter B (AC)m (AG)n repeats and atrophy of the brain and the cerebellum. Occurrence of these lesions was correlated with a decrease of alcohol tolerance, withdrawal symptoms--especially delirium tremens.
MeSH terms
-
Adult
-
Alcoholism / genetics*
-
Alcoholism / pathology*
-
Atrophy
-
Brain / pathology*
-
Cerebellum / pathology
-
Eye Proteins
-
Female
-
Homeodomain Proteins / genetics*
-
Humans
-
Male
-
Middle Aged
-
PAX6 Transcription Factor
-
Paired Box Transcription Factors
-
Polymorphism, Genetic*
-
Promoter Regions, Genetic*
-
Repressor Proteins
Substances
-
Eye Proteins
-
Homeodomain Proteins
-
PAX6 Transcription Factor
-
PAX6 protein, human
-
Paired Box Transcription Factors
-
Repressor Proteins