PI 3-kinases and PTEN: how opposites chemoattract

Cell. 2002 May 31;109(5):541-4. doi: 10.1016/s0092-8674(02)00765-1.

Abstract

Phosphatidylinositol lipids, such as PI(4,5)P2 and PI(3,4,5)P3, are key mediators in diverse intracellular signaling pathways. Two recent reports examine how the metabolism of these lipids by phosphatidylinositol 3-kinases and the PTEN 3-phosphoinositide phosphatase may coordinate G protein coupled signaling pathways during eukaryotic chemotaxis.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Cell Polarity / physiology
  • Chemotaxis / physiology*
  • Dictyostelium / cytology
  • Dictyostelium / metabolism
  • Eukaryotic Cells / cytology
  • Eukaryotic Cells / enzymology*
  • Humans
  • PTEN Phosphohydrolase
  • Phosphatidylinositol 3-Kinases / metabolism*
  • Phosphatidylinositols / metabolism*
  • Phosphoric Monoester Hydrolases / metabolism*
  • Signal Transduction / physiology*
  • Tumor Suppressor Proteins / metabolism*

Substances

  • Phosphatidylinositols
  • Tumor Suppressor Proteins
  • Phosphatidylinositol 3-Kinases
  • Phosphoric Monoester Hydrolases
  • PTEN Phosphohydrolase
  • PTEN protein, human