Abstract
Animals sense many environmental stimuli simultaneously and integrate various sensory signals within the nervous system both to generate proper behavioral responses and also to form relevant memories. HEN-1, a secretory protein with an LDL receptor motif, regulates such processes in Caenorhabditis elegans. The hen-1 mutants show defects in the integration of two sensory signals and in behavioral plasticity by paired stimuli, although their sensation capability seems to be identical to that of the wild-type. The HEN-1 protein is expressed in two pairs of neurons, but expression in other neurons is sufficient for wild-type behavior. In addition, expression of HEN-1 at the adult stage is sufficient. Thus, HEN-1 regulates sensory processing non-cell-autonomously in the mature neuronal circuit.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amino Acid Motifs / genetics
-
Animals
-
Bodily Secretions / physiology
-
Caenorhabditis elegans / cytology
-
Caenorhabditis elegans / metabolism*
-
Caenorhabditis elegans Proteins / genetics
-
Caenorhabditis elegans Proteins / isolation & purification*
-
Caenorhabditis elegans Proteins / metabolism
-
Evolution, Molecular
-
Gene Expression Regulation / physiology
-
Homeodomain Proteins / genetics
-
Learning / physiology*
-
Nerve Tissue Proteins / genetics
-
Nerve Tissue Proteins / isolation & purification*
-
Nerve Tissue Proteins / metabolism
-
Nervous System / cytology
-
Nervous System / growth & development*
-
Nervous System / metabolism
-
Neural Pathways / cytology
-
Neural Pathways / growth & development*
-
Neural Pathways / metabolism
-
Neurons / cytology
-
Neurons / metabolism*
-
Neuropeptides / deficiency
-
Neuropeptides / genetics
-
Phenotype
-
Phylogeny
-
Receptors, LDL / chemistry
-
Receptors, LDL / genetics
-
Sensation / genetics*
-
Signal Transduction / genetics
Substances
-
Caenorhabditis elegans Proteins
-
HEN-1 protein, C elegans
-
Homeodomain Proteins
-
Nerve Tissue Proteins
-
Neuropeptides
-
Receptors, LDL
-
TTX-3 protein, C elegans