Hydrolysis in pharmaceutical formulations

Pharm Dev Technol. 2002 May;7(2):113-46. doi: 10.1081/pdt-120003494.

Abstract

This literature review presents hydrolysis of active pharmaceutical ingredients as well as the effects on dosage form stability due to hydrolysis of excipients. Mechanisms and measurement methods are discussed and recommendations for formulation stabilization are listed.

Publication types

  • Review

MeSH terms

  • Buffers
  • Catalysis
  • Chemistry, Pharmaceutical*
  • Dosage Forms
  • Drug Packaging
  • Drug Stability*
  • Excipients / chemistry
  • Hydrogen-Ion Concentration
  • Hydrolysis
  • Models, Chemical
  • Prodrugs / metabolism
  • Suspensions

Substances

  • Buffers
  • Dosage Forms
  • Excipients
  • Prodrugs
  • Suspensions