The putative haemobartonella that influences Plasmodium falciparum parasitaemia in squirrel monkeys is a haemotrophic mycoplasma

Microbes Infect. 2002 Jun;4(7):693-8. doi: 10.1016/s1286-4579(02)01588-5.

Abstract

Splenectomised squirrel monkeys (Saimiri sciureus) are increasingly being used as an experimental host for human malaria studies, notably for the assessment of candidate vaccines against Plasmodium falciparum blood-stage infection. Recently, S. sciureus monkeys in our primate-breeding colony were reported to be asymptomatic carriers of a putative Haemobartonella species. Patent haemobartonella infection is frequently activated following splenectomy, and may interfere with studies on the course of P. falciparum parasitaemia in these animals. Here, we show by 16S rRNA gene sequence analysis that this wall-less bacterium is not a rickettsia but, instead, is a haemotrophic mycoplasma. Haemotrophic mycoplasmas are a newly identified group of mycoplasmas that parasitise the surfaces of erythrocytes of a wide variety of vertebrate hosts.

MeSH terms

  • Animals
  • Disease Models, Animal
  • Erythrocytes / microbiology
  • Erythrocytes / ultrastructure
  • Genes, Bacterial / genetics
  • Malaria, Falciparum / complications*
  • Monkey Diseases / microbiology
  • Monkey Diseases / parasitology
  • Mycoplasma / classification
  • Mycoplasma / genetics
  • Mycoplasma / isolation & purification*
  • Mycoplasma / ultrastructure
  • Mycoplasma Infections / complications*
  • Mycoplasma Infections / drug therapy
  • Mycoplasma Infections / microbiology
  • Mycoplasma Infections / veterinary*
  • Parasitemia / complications*
  • Phylogeny
  • Plasmodium falciparum
  • Polymerase Chain Reaction
  • RNA, Ribosomal, 16S / genetics
  • Saimiri / microbiology*
  • Saimiri / parasitology*
  • Splenectomy

Substances

  • RNA, Ribosomal, 16S