The effect of tilmicosin on cardiac superoxide dismutase and glutathione peroxidase activities

E Yazar; V Altunok; M Elmas; B Traş; A L Baş; V Ozdemir

doi:10.1046/j.1439-0450.2002.00545.x

The effect of tilmicosin on cardiac superoxide dismutase and glutathione peroxidase activities

J Vet Med B Infect Dis Vet Public Health. 2002 May;49(4):209-10. doi: 10.1046/j.1439-0450.2002.00545.x.

Authors

E Yazar¹, V Altunok, M Elmas, B Traş, A L Baş, V Ozdemir

Affiliation

¹ Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selcuk, Konya, Turkey.

PMID: 12069277
DOI: 10.1046/j.1439-0450.2002.00545.x

Abstract

In this study, the effect of tilmicosin on cardiac superoxide dismutase and glutathione peroxidase activities was investigated. Forty male BALB/c mice were used as material. Ten mice served as a control group, and 30 mice were injected with tilmicosin (25 mg/kg body weight, subcutaneously, with a single injection). After drug administration, they were monitored for 3 days. Tilmicosin caused decreases in cardiac superoxide dismutase and glutathione peroxidase activities.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Bacterial Agents / pharmacology*
Glutathione Peroxidase / drug effects
Glutathione Peroxidase / metabolism*
Heart / drug effects*
Macrolides*
Male
Mice
Mice, Inbred BALB C
Myocardium / enzymology*
Superoxide Dismutase / drug effects
Superoxide Dismutase / metabolism*
Tylosin / analogs & derivatives*
Tylosin / pharmacology*

Substances

Anti-Bacterial Agents
Macrolides
Glutathione Peroxidase
Superoxide Dismutase
tilmicosin
Tylosin