Linkage of Patr-AL to Patr-A and- B in the major histocompatibility complex of the common chimpanzee (Pan troglodytes)

Immunogenetics. 2002 Jun;54(3):212-5. doi: 10.1007/s00251-002-0452-x. Epub 2002 Apr 11.

Abstract

Patr-AL is a recently described gene found only in the common chimpanzee, but closely related in structure to the highly polymorphic Patr-A and HLA-A genes of the chimpanzee and human MHCs, respectively. Unlike Patr-A and HLA-A, the Patr-AL gene has little polymorphism and is not fixed in the chimpanzee genome. To determine whether Patr-AL is located in the MHC or elsewhere, we compared segregation of the Patr-AL gene with segregation of Patr-A and - B alleles in chimpanzee families. The results demonstrate that Patr-AL is an MHC class I gene present on different MHC haplotypes as defined by their combination of Patr-A and B alleles.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Female
  • Gene Frequency
  • Genes, MHC Class I*
  • Genetic Linkage*
  • Haplotypes
  • Histocompatibility Antigens Class I / genetics*
  • Male
  • Pan troglodytes / genetics*
  • Pedigree
  • Polymorphism, Single-Stranded Conformational

Substances

  • Histocompatibility Antigens Class I