A kinetic study of reactions of Et3ZnLi and di-tert-butyl ketone

Keith M Maclin; Herman G Richey Jr

doi:10.1021/jo0111659

A kinetic study of reactions of Et3ZnLi and di-tert-butyl ketone

J Org Chem. 2002 Jun 28;67(13):4602-4. doi: 10.1021/jo0111659.

Authors

Keith M Maclin¹, Herman G Richey Jr

Affiliation

¹ Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania l6802, USA.

PMID: 12076165
DOI: 10.1021/jo0111659

Abstract

An organozincate of composition Et3ZnLi and di-tert-butyl ketone react in toluene to form (after hydrolysis) ethyl-di-tert-butylmethanol. The rate is proportional to approximately [Et3ZnLi](-0.5)[ketone](1) when the initial concentration of Et3ZnLi is greater than that of the ketone but proportional to [Et3ZnLi](1)[ketone](-1) when the initial concentration of ketone is greater than that of Et3ZnLi. The rate of addition of Et3ZnK to di-tert-butyl ketone is <10(-4) that of Et3ZnLi.