Abstract
The Mononegavirales virus group comprises several major human pathogens, including measles, rabies and Ebola viruses. This article reports a computational analysis of the C-terminal region of RNA-dependent RNA-polymerases from Mononegavirales. Using a combination of sequence similarity and threading analysis, a 2'-O-ribose methyltransferase domain was identified that is involved in the capping of viral mRNAs.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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DNA-Directed RNA Polymerases / chemistry*
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DNA-Directed RNA Polymerases / genetics*
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DNA-Directed RNA Polymerases / metabolism
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Humans
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Methyltransferases / chemistry*
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Methyltransferases / genetics*
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Methyltransferases / metabolism
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Molecular Sequence Data
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Mononegavirales / enzymology*
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Mononegavirales / genetics
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Protein Structure, Tertiary
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RNA Caps / metabolism*
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RNA Processing, Post-Transcriptional*
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RNA, Viral / metabolism
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Sequence Alignment
Substances
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RNA Caps
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RNA, Viral
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Methyltransferases
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DNA-Directed RNA Polymerases