Lyme disease (LD) is the most common vector-borne disease in the United States. Generally presenting with a characteristic rash, myalgia, and fatigue, LD can progress to chronic arthritis, central nervous system manifestations, and cardiac abnormalities, if left untreated. The number of cases continues to rise each year. Early diagnosis and proper therapy are required to halt disease progression to late chronic stages. By adhering to simple guidelines, many potential cases of LD can be prevented. In this article, the second in a 2-part series on LD, we discuss clinical features and treatment.