Objective: To investigate the changes of oxygen supply and demand balance during total hepatectomy and partial liver replantation(TCH and PLRP) with venous bypass technique in pigs.
Methods: Seven young pigs[weight (24.2 +/- 4.8) kg] were anesthetized with fentanyl and pentobartal. Catheters were inserted into portal vein via splenic vein and into vena cava inferior via right femoral vein, respectively, and the two catheters were connected by a "Y" adaptor to right atrium via extracorporeal circulation pump. Venous bypass technique was used during occlusion of total hepatic blood stream(OTHB). SvO2, hemodynamics and blood gas analysis were measured after anesthesia, during and 30 minutes after venous bypass.
Results: SvO2 was decreased significantly(P < 0.05), vein bypass technique ameliorated partially the disturbance of hemodynamics, and there was correlation between CO and SvO2 during THC and PLRP in pigs.
Conclusion: The results suggest that there is oxygen supply and demand unbalance during THC and PLRP with venous bypass technique in pigs, and it is beneficial to monitor oxygen ladder during operation.