Clathrin adaptors really adapt

Cell. 2002 May 17;109(4):413-6. doi: 10.1016/s0092-8674(02)00751-1.

Abstract

The clathrin pathway is the principal route for receptor-mediated endocytosis and growth factor downregulation. Heterotetrameric clathrin adaptors directly link the clathrin coat with cargo transmembrane proteins that are sorted into coated pits and vesicles. A paper in this issue of Cell describes the atomic structure of the adaptor-protein 2 (AP-2) core, the portion that makes contacts with the membrane and cytosolic tails of cargo proteins.

Publication types

  • Review

MeSH terms

  • Adaptor Proteins, Vesicular Transport
  • Animals
  • Carrier Proteins / metabolism*
  • Cell Membrane / metabolism*
  • Cell Membrane / ultrastructure
  • Clathrin / metabolism*
  • Endocytosis / physiology*
  • Eukaryotic Cells / metabolism*
  • Eukaryotic Cells / ultrastructure
  • Humans
  • Membrane Proteins / metabolism*
  • Molecular Structure
  • Protein Transport / physiology*
  • Signal Transduction / physiology

Substances

  • Adaptor Proteins, Vesicular Transport
  • Carrier Proteins
  • Clathrin
  • Membrane Proteins