Two HIFs may be better than one

Cancer Cell. 2002 Apr;1(3):211-3. doi: 10.1016/s1535-6108(02)00048-x.

Abstract

HIF-2alpha overexpression directly contributes to renal clear cell tumorigenesis: evidence for HIF as a tumor promoter.

Publication types

  • Editorial
  • Comment

MeSH terms

  • Animals
  • Basic Helix-Loop-Helix Transcription Factors
  • Carcinoma, Renal Cell / metabolism*
  • Carcinoma, Renal Cell / pathology
  • Cell Division
  • Genes, Tumor Suppressor
  • Humans
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Kidney Neoplasms / genetics
  • Kidney Neoplasms / metabolism*
  • Kidney Neoplasms / pathology
  • Ligases / metabolism
  • Trans-Activators / metabolism*
  • Transcription Factors / metabolism
  • Tumor Suppressor Proteins*
  • Ubiquitin-Protein Ligases*
  • Von Hippel-Lindau Tumor Suppressor Protein

Substances

  • Basic Helix-Loop-Helix Transcription Factors
  • HIF1A protein, human
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Trans-Activators
  • Transcription Factors
  • Tumor Suppressor Proteins
  • endothelial PAS domain-containing protein 1
  • Ubiquitin-Protein Ligases
  • Von Hippel-Lindau Tumor Suppressor Protein
  • Ligases
  • VHL protein, human