Abstract
Three adult patients in Naples, Italy, had meningitis due to multiple drug-resistant serotype 24F Streptococcus pneumoniae isolates. The 3 isolates were genetically indistinguishable and shared pbp2b and pspA sequence types with previously characterized penicillin-resistant clones. This serotype 24F strain was found to be the same clonal type as a previously characterized, penicillin-resistant serotype 14 strain. The novel strain has probably arisen through transformation of a serotype 14 strain with type 24F capsular biosynthetic operon sequences.
Publication types
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Case Reports
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Drug Resistance, Multiple, Bacterial* / genetics
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Humans
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Italy / epidemiology
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Male
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Meningitis, Pneumococcal / cerebrospinal fluid
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Meningitis, Pneumococcal / diagnosis
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Meningitis, Pneumococcal / drug therapy*
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Meningitis, Pneumococcal / genetics
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Middle Aged
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Serotyping
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Streptococcus pneumoniae / classification*
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Streptococcus pneumoniae / drug effects
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Streptococcus pneumoniae / genetics
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Streptococcus pneumoniae / isolation & purification*
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Treatment Outcome