Abstract
Eight new polyketide-derived metabolites [cladoacetals A and B (1 and 2), 3-(2-formyl-3-hydroxyphenyl)propionic acid (3), 3-deoxyisoochracinic acid (4), isoochracinol (5), 7-hydroxy-3-(2,3-dihydroxybutyl)-1(3H)-isobenzofuranone (6), (+)-cyclosordariolone (10), and altersolanol J (11)] and six known metabolites [two isomeric 1-(1,3-dihydro-4-hydroxy-1-isobenzofuranyl)butan-2,3-diols (7a/b), 7-hydroxy-1(3H)-isobenzofuranone (8), isoochracinic acid (9), altersolanol A (12), and macrosporin (13)] have been isolated from solid-substrate fermentation cultures of an undetermined fungicolous isolate (NRRL 29097) that resembles Cladosporium sp. All structures were assigned primarily by analysis of 1D and/or 2D NMR data. Five of the compounds showed antibacterial activity.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Anti-Bacterial Agents
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / isolation & purification*
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Anti-Infective Agents / pharmacology
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Aspergillus flavus / drug effects
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Bacillus subtilis / drug effects
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Candida albicans / drug effects
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Fusarium / drug effects
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Hydrolysis
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Microbial Sensitivity Tests
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Mitosporic Fungi / chemistry*
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Polycyclic Aromatic Hydrocarbons / chemistry
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Polycyclic Aromatic Hydrocarbons / isolation & purification*
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Polycyclic Aromatic Hydrocarbons / pharmacology
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Spectrometry, Mass, Electrospray Ionization
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Staphylococcus aureus / drug effects
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Stereoisomerism
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents
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Polycyclic Aromatic Hydrocarbons