Abstract
Artemisinin 1, dihydro-epideoxyarteannuin B 2 and deoxyartemisinin 3 were isolated from the sequiterpene lactone-enriched fraction obtained from the crude ethanolic extract of Artemisia annua L. These compounds were tested on ethanol and indomethacin-induced ulcer models. Compound 1 did not afford cytoprotection under the experimental models tested. Only compounds 2 and 3 decreased the ulcerative lesion index produced by ethanol and indomethacin in rats. These compounds did not demonstrate antiulcerogenic activity when tested on the ethanol-induced ulcer model, with previous administration of indomethacin, suggesting that the antiulcerogenic activity is a consequence of prostaglandin synthesis increase.
MeSH terms
-
Animals
-
Anti-Ulcer Agents / chemistry
-
Anti-Ulcer Agents / pharmacology*
-
Anti-Ulcer Agents / therapeutic use
-
Artemisinins*
-
Asteraceae*
-
Carbenoxolone / pharmacology
-
Cimetidine / pharmacology
-
Drug Interactions
-
Ethanol / administration & dosage
-
Indomethacin / administration & dosage
-
Male
-
Phytotherapy
-
Plant Extracts / chemistry
-
Plant Extracts / pharmacology
-
Plant Extracts / therapeutic use
-
Rats
-
Rats, Wistar
-
Sesquiterpenes / chemistry
-
Sesquiterpenes / isolation & purification
-
Sesquiterpenes / pharmacology*
-
Sesquiterpenes / therapeutic use
-
Stomach / drug effects*
-
Stomach / pathology
-
Stomach Ulcer / chemically induced
-
Stomach Ulcer / drug therapy*
Substances
-
Anti-Ulcer Agents
-
Artemisinins
-
Plant Extracts
-
Sesquiterpenes
-
deoxyartemisinin 3
-
Ethanol
-
deoxyartemisinin
-
Cimetidine
-
artemisinin
-
Carbenoxolone
-
Indomethacin