Antiestrogenic regulation of transforming growth factor beta receptors I and II in human breast cancer cells

M Buck; J von der Fecht; C Knabbe

doi:10.1111/j.1749-6632.2002.tb04104.x

Antiestrogenic regulation of transforming growth factor beta receptors I and II in human breast cancer cells

Ann N Y Acad Sci. 2002 Jun:963:140-3. doi: 10.1111/j.1749-6632.2002.tb04104.x.

Authors

M Buck¹, J von der Fecht, C Knabbe

Affiliation

¹ Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology and Robert Bosch Hospital, Department of Clinical Chemistry, 70376 Stuttgart, Germany. [email protected]

PMID: 12095938
DOI: 10.1111/j.1749-6632.2002.tb04104.x

Abstract

To obtain more information about the interactions between antiestrogens and transforming growth factor beta (TGF-beta) signaling, we analyzed the influence of different types of antiestrogens on the expression of TGF-beta receptors I (TbetaRI) and II (TbetaRII). Our results show that antiestrogens selectively induce TbetaRII but not TbetaRI mRNA.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Breast Neoplasms / metabolism*
Estrogen Receptor Modulators / pharmacology*
Humans
Protein Serine-Threonine Kinases
RNA, Messenger / drug effects
RNA, Messenger / metabolism
Receptor, Transforming Growth Factor-beta Type II
Receptors, Transforming Growth Factor beta / genetics
Receptors, Transforming Growth Factor beta / metabolism*

Substances

Estrogen Receptor Modulators
RNA, Messenger
Receptors, Transforming Growth Factor beta
Protein Serine-Threonine Kinases
Receptor, Transforming Growth Factor-beta Type II