p53 and anti-p53 antibodies as possible markers of a switch towards a neoplastic phenotype in patients infected by Helicobacter pylori

E Losi; A M Molinari; P Gazzerro; L Ortega De Luna; M T Fera; M Carbone; M R Catania; D L Hasty; F Rossano

doi:10.1111/j.1749-6632.2002.tb04126.x

p53 and anti-p53 antibodies as possible markers of a switch towards a neoplastic phenotype in patients infected by Helicobacter pylori

Ann N Y Acad Sci. 2002 Jun:963:329-31. doi: 10.1111/j.1749-6632.2002.tb04126.x.

Authors

E Losi¹, A M Molinari, P Gazzerro, L Ortega De Luna, M T Fera, M Carbone, M R Catania, D L Hasty, F Rossano

Affiliation

¹ Istituto Nazionale per la Ricerca sul Cancro - Genova, Unità Satellite di Messina, Messina, Italy.

PMID: 12095960
DOI: 10.1111/j.1749-6632.2002.tb04126.x

Abstract

Helicobacter pylori is a definite carcinogen whose mechanism of action is still unknown. The aim of this work was (1) to determine the presence of p53 protein and related antibodies in patients affected by various gastric pathologies and chronically infected with H. pylori, and (2) to try to discover a test to be used as a marker of a possible switch towards a neoplastic phenotype.

MeSH terms

Antibodies / immunology
Cell Transformation, Neoplastic / immunology
Cell Transformation, Neoplastic / metabolism*
Helicobacter Infections / immunology
Helicobacter Infections / metabolism
Helicobacter Infections / physiopathology*
Helicobacter pylori*
Humans
Phenotype
Tumor Suppressor Protein p53 / immunology
Tumor Suppressor Protein p53 / metabolism*

Substances

Antibodies
Tumor Suppressor Protein p53